Approaches of bronchial asthma treatment:
- Prevention of exposure to allergens
- Reduction of bronchial inflammation and hyper reactivity
- Dilatation of narrowed bronchi
Drugs used in Bronchial asthma
A. Bronchodilators:
1. Sympathomimetic drugs:
a. Selective β2 agonist.Short acting (duration 4-6 hrs) –
- Salbutamol
- Terbutaline
- Metaproterenol
- Salmeterol
- Fenoterol
- Formeterol
- Rimeterol
- Bitolterol
b. Non selective (β1 & β2)
- Adrenaline
- Ephedrine
- Isoproterenol (Isoprenaline).
2. Methyl xanthene group:
Natural –
- Theophylline
- Theobromine
- Caffeine (also used in neonatal apnoea)
Synthetic –
- Aminophylline. (Na salt of Theiophylin)
3. Antimuscarinic bronchodilator:
- Ipratropium
- Oxitropium
B. Anti-inflammatory
1. Corticosteroids:- Hydrocortisone. (Inj.)
- Prednisolone. (Oral)
- Beclomethasone
- Budesonide
- Triamcinolone
- Flunisolide
- Fluticasone
- Mometason
2 . Mast cell stabilizer:
- Nedocromil sodium
- Cromolyn sodium ( disodium chromoglycate) drugs
C. Others:
1. Leukotrine pathway inhibitor –
- Zileuton
- Zafirlukast
- Montelukast
2. Calcium channel blocker –
- Nifedipine
- Verapamil
- Amlodipine
3. Anti IgE monoclonal antibody:
- Omalizumab
4. Histamin (H1 ) receptor blocker:
- Ketotifen
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